PARTICLE SIZE

PARTICLE SIZE :

Active Pharmaceutical Ingredients have several important physical properties including polymorphism, water content, density and particle size. Particle Size Distribution, or PSD, has a direct influence on material properties such as: flowability, handling, dissolution rate, stability, and efficacy of delivery
Common methods of particle size measurement
  • Sieves. While this is an old technique, it has the advantage of being cheap and particularly useful for the measurement of large particles. ...
  • Sedimentation. This has been a common method used (historically) in clay and ceramics industries. 
  • Electrozone testing.
  • Laser Diffraction.

Particle sizes are measured in microns (μ). A micron is 1/1000 mm. or 1/25,400 in. A millimicron (mμ) is 1/1000 of a micron, or 1/1,000,000 mm. Usually particle size is designated as the average diameter in microns, although some literature reports particle radius.









what is D10,D50 and D90 in particle size?

In the laser diffraction method, “D10”, “D50”, “D90” (horizontal axis) and “volume percentage (Volume (%))” (vertical axis) indicate the following values.
D10: The portion of particles with diameters smaller than this value is 10%
D50: The portions of particles with diameters smaller and larger than this value are 50%. Also known as the median diameter.
D90: The portion of particles with diameters below this value is 90%.




Volume percentage: The highest volume percentage of the particle size distribution displayed.

graph

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